The two most-stacked healing peptides. Mechanism, dosing, and when to pick which.
Synthetic pentadecapeptide. Strong animal data, almost no human data — and the most-Googled healing peptide of the decade.
Read full guide → Thymosin β-4 fragmentThe systemic healing peptide — built for muscle tears and full-body inflammation, where BPC-157 cannot reach.
Read full guide →| BPC-157 | TB-500 | |
|---|---|---|
| Mechanism | Angiogenesis (VEGFR2/eNOS), GH-receptor upregulation | Actin regulation, cell migration, anti-inflammation |
| Best for | Tendons, ligaments, gut lining | Muscle tears, systemic inflammation |
| Route | Subcutaneous (injury) or oral (gut) | Subcutaneous |
| Half-life | Short (minutes to hours) | Long (days) |
| Typical dose | 250-500 mcg / day | 2.5 mg twice a week |
| Cycle | 4-8 weeks | 6-8 weeks |
| Stack synergy | Excellent with TB-500 | Excellent with BPC-157 |
| WADA | Banned (S0) | Banned (S2) |
| Cost / month | $80-120 (research) | $120-180 (research) |
The two compounds operate on non-competing biological systems. BPC-157 promotes localized angiogenesis and growth-factor receptor upregulation, while TB-500 (Thymosin β-4) regulates actin and cell migration body-wide. Combined, they cover both the local wound site and the systemic inflammatory environment — which is why the "Wolverine stack" is the most popular healing protocol in the community.
Localized soft-tissue injuries: an Achilles tendon, a rotator cuff tear, plantar fasciitis. Gastrointestinal issues: leaky gut, NSAID-induced ulcers (where oral BPC-157 is the only viable peptide route). Lower cost and a 4-week cycle for acute injuries.
Large muscle-belly tears (hamstring, quad) where systemic distribution helps. Full-body inflammatory states. Joint issues where the injury site is hard to target locally. Longer half-life means twice-weekly injections instead of daily.
Severe acute injuries — Grade 2/3 tears, post-surgical recovery, multi-site issues. The community standard is BPC-157 500 mcg daily SC + TB-500 2.5 mg 2× per week SC, for 6–8 weeks.
Epti lets you log your protocol — every dose, side-effect, and outcome on one timeline. The only way to know which works for you.